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HiPep Laboratories
【Field/Business】
Medical care/Diagnosis/Medical equipment/Healthcare
Drug discovery support/Contract service
Pharmaceutical/Drug Discovery
last update:2022/6/8
Profile

Delegates :
Dr. Kiyoshi Nokihara


Incorporated :
March  29 , 2002

Paid in Capital :
22 Million yen  

Employees :
8 人

Address :
Nakatsukasa-cho, 486-46, Kamigyo-ku, Kyoto, 602-8158, Japan KYOTO
〒602-8158

TEL/FAX :
+81-75-813-2101 / +81-75-801-0280

URL:
httsp://www.hipep.com

Attachment :
HiPep_O-001E_2022.pdf [ 1.7MiB ]

Mission/Background :
Based on academic research in an interdisciplinary field as well as business experiences, HiPep Laboratories was founded in 2002 focusing on applications of molecular recognition, diagnostics and theranostics. The concept is that biomolecules such as proteins can be mimicked by peptides. Recently development of microarray systems, PepTenChip (R), for biodetection has been completed. In addition to proteins, DNA recognition by peptides consisting of pyrrole and imidazole (PIPA) has been also commercialized.

Technology & Business
The core technology, designated HiPep(R) Technology, is highly efficient construction and characterization of structured peptides and their conjugates. HiPep has developed unique laboratory devices and reagents for in-house use and delivered as commercial products in research supporting. Products/licensing/collaboration as follows:
[1] Novel biodetection systems, PepTenChip(R);
[2] Libraries of peptides and cyclotides immobilized on gel-type beads based on the “one peptide on one bead" concept (diversity: ca 200 millions); bio-conjugates (drug delivery technology, peptide-vehicles). Novel focusing drug-likeness libraries. Deconvolution service available.
[3] Angiogenic peptides for regenerative medicine (US, EU & JP-PAT) which showed no permeation;
[4] Non-proteinogenic amino acid, Mimosine, and derivatives.
[5] Reagents, devices with consumers and unique HPLC-columns originally developed for in-house use.
[6] PIPA-derivatives for gene-control, DNA visualization and API.
[7] Contract research.
Products & Service
Products & Service Name
Stage
Outline
Milestone
PepTenChip(R), novel biodetection systems
Preclinical
Peptides micro array, non-disposable amorphous carbon plates, detector
Clinical tests followed by approval (medical device category I)
Angiogenic peptides and their conjugates
Preclinical
Strong angiogenesis and SAR, endogenous enzyme resistant
Licensing and collaboration for clinical tests
Pyrrole Imidazole Polyamide, PIPA
Preclinical
API, Prove for DNA visualization
Telomere visualization; GMP-production is planned.
Devices/consumers
Launched
Efficient library construction, technology know-how transfer
Bio-detection, drug development, cancer-DDS, cosmeceuticals
Mimosine, non-proteinogenic amino acid, and mimosyl-peptides
Discovery
Mimosyl-peptides for API or cosmeceutical ingredients
Material supply/collaboration
Highlights
1. Novel biodetection system, PepTenChip(R), arrayed with labeled structured peptides for bio-detection (patented: EU, US & JP) is completed together with chip-substrate made from amorphous carbon. The maintenance free detector, PepTenCam, is also launched.
2. Production system for PIPA (peptides consisting of pyrrole and imidazole as major building blocks), recognizing DNA with sequence specific manner, has been performed. PIPA can be applied to novel drugs and molecular probes for DNA.
Hot news
PepTenChip(R) provides objective results. Preclinical experiments in neuronal diseases and pre-cancer detection are underway. The system allows noninvasive diagnostics, real-time on-site POC, thus it can be applied to remote diagnostics and home medical-care.
Alliance strategy
Technology transfer concerning to biomolecular recognition and product sales: the novel bio-detection system; various peptide-based libraries for drug discovery and optimization; bio-conjugates (peptide-vehicle for DDS); long lasting angiogenic agents for regenerative medicine; PIPA for DNA-targeting probes or API; non-proteinogenic amino acid, mimosine containing derivatives as novel ingredients of drugs or cosmeceuticals. Consultation and contract research.

 
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